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KMID : 1123920100240030476
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 3 p.476 ~ p.483
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Anxiolytic-like Effects of Scrophularia buergeriana Miquel Using the Elevated Plus-Maze in Mice : Involvement of GABAergic Nervous System
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Choi Yun-Hee
Jung Ji-Wook
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Abstract
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The present study was performed to investigate the putative anxiolytic-like effects of the aqueous extract of the roots of Scrophularia buergeriana (SB-W) using elevated plus-maze (EPM) and hole-board apparatus in mice. SB-W was orally administered at doses of 50, 100, 200 or 400 mg/kg to ICR mice, 1 h before the behavioral evaluation. Control group were administered with an equal volume of saline, and positive control group with buspirone (2 mg/kg, i.p.). The administration of SB-W significantly increased the percentage of time spent in open arms and entries into the open arms of the EPM compared with saline-treated control group (P < 0.05). Futhermore, those anxiolytic-like activities of SB-W were antagonized by flumazenil (a antagonist, 10 mg/kg), but not by WAY-100635 (a 5- antagonist, 0.3 mg/kg). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with saline-treated control group. In the hole-board test, the administration of SB-W (200 and 400 mg/kg) significantly increased the number of head-dipping compared with saline-treated control group (P < 0.05). Therefore, these findings suggest that Scrophularia buergeriana promotes the anxiolytic-like activity mediated by GABAergic nervous system in mice.
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KEYWORD
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Anxiety, Scrophularia buergeriana, Elevated plus-maze, WAY 100635, Flumazenil
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